Protein Modification Reagents
Medchemexpress LLC Aminooxy-PEG2-azide | 1043426-13-6 | ≥96.0% | 190.20 | 250 MG
Aminooxy-PEG2-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs and as a non-cleavable 2-unit PEG ADC linker for antibody-drug conjugates. It functions as a click chemistry reagent with an Azide group.
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Utilized in the synthesis of PROTACs.
- Employed in the synthesis of antibody-drug conjugates (ADCs).
eMolecules Broadpharm / TCO-PEG12-NHS ester / 10mg / 433947089 / BP-24123 / 95.000 / 2185016-39-9 / MFCD30536161 / 866.996 / C40H70N2O18
Broadpharm / TCO-PEG12-NHS ester / 10mg / 433947089 / BP-24123 / 95.000 / 2185016-39-9 / MFCD30536161 / 866.996 / C40H70N2O18
GENOVIS INC FucosEXO, 2000 units, Origin: E. Coli
FucosEXO is a mix of a-fucosidases for efficient hydrolysis of a1-2, a1-3 and a1-4-linked fucose on N- and O-glycosylated proteins or free oligosaccharides. FucosEXO is available as a 2000 units lyophilized fucosidase mix for hydrolysis of fucose from 2 mg glycoprotein.
Medchemexpress LLC Biotin-PEG2-Mal | 305372-39-8 | 99.6% | 525.62 | 250 MG
Biotin-PEG2-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in protac synthesis
- Facilitates degradation of target proteins
- Exploits the ubiquitin-proteasome system
Medchemexpress LLC Cyclin K degrader 1 | 3055008-98-2 | 99.9% | 466.32 | 5 MG
Cyclin K degrader 1 (compound 40) is an AT7519 based Cyclin K degrader with a DC50 of 21 nM. It demonstrates an affinity for cyclin K that is approximately 500-fold higher than its affinity for CDK12.
- Degrades cyclin K in the presence of DDB-1.
- Achieves 99 ± 1 % cyclin K degradation.
- Has a DC50 of 21 nM.
- Exhibits Dmax >95%.
- Features a CDK12 Kd of 1000 nM.
Medchemexpress LLC PROTAC EGFR degrader 9 | 2992670-33-2 | 98.4% | 899.98 | 5 MG
PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. It demonstrates a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. This degrader exhibits potent degradation activity against various EGFR mutants while sparing EGFRWT. The compound is for research use only and not sold to patients.
- Orally active CRBN-based PROTAC EGFR degrader.
- Exhibits potent degradation activity against various EGFR mutants (EGFRL858R/T790M/C797S, EGFRdel19 T790M C797S, EGFRL858R/T790M, EGFRdel19).
- Spares EGFRWT.
- Inhibits NSCLC tumor growth in vivo without obvious toxicity.
- Reduces EGFR protein level and inhibits EGFR phosphorylation in tumor tissues.
- Arrests H1975-TM cells in the G0/G1 phase.
- Promotes cell apoptosis in H1975-TM cells.
Medchemexpress LLC DSPE-PEG carboxylic acid (sodium) | 1403744-37-5 | 2000 (average) | (C2H4O)nC45H86NO12P.Na | 5 MG
DSPE-PEG carboxylic acid (sodium), MW 2000 is a polyethylene glycol-conjugated phospholipid with a terminal carboxylate (sodium salt). It is used as a PEG-lipid component for formulating liposomes and nanoparticle drug delivery systems to improve circulation time, stability, and surface functionalization.
- PEG-lipid with terminal carboxylate (sodium salt) enabling conjugation and surface modification.
- Average molecular weight approximately 2000, suitable for PEGylation and stealth coatings.
- Improves liposome circulation time and colloidal stability.
- Enhances targeting potential and cellular uptake when formulated into nanoparticles.
- Solid, white to off-white form for convenient handling and storage.
ABclonal Technology PLA2G7 Rabbit pAb
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.
Medchemexpress LLC PROTAC EGFR degrader 11 | 3034244-71-5 | 99.2% | 991.61 | 1 MG
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. It binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
- PROTAC degrader for epidermal growth factor receptor (EGFR).
- DC50 <100 nM.
- Binds CRBN-DDB1 with a Ki of 36 nM.
- Degrades EGFR, focal adhesion kinase (FAK), and RSK1.
- Inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
Medchemexpress LLC DBCO-PEG6-NHS ester | 95.99% | 737.79 | 25 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing an NHS ester that reacts specifically with primary amines, such as side chains of lysine residues or aminosilane-coated surfaces, under neutral or slightly alkaline conditions, to form covalent bonds. It also contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Reacts specifically with primary amines via NHS ester
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Suitable for covalent bond formation
- Useful in click chemistry reactions
Medchemexpress LLC Dmg-peg-nhs | 95.0% | 2000 (Average) | 25 MG
This compound is composed of Myristic acid and PEG linked by an amide bond, with NHS as an active ester group attached to the end of the PEG chain. It is suitable for various applications including protein/biomolecule modification, gene delivery, and biosensor applications.
- Used for protein/biomolecule modification
- Suitable for gene delivery
- Applicable in biosensor applications
- For research use only